Basic Molecular Information

Basic Information

DICL ID
DICL_CP_0309964
PubChem CID
Molecular Formula
C8H8ClN3
Molecular Weight
181.626 g/mol
Synonyms/Alias
[CHEMBL536539; CHEMBL2436555; CHEMBL1188501; BDBM50371441; BDBM50441458; 2-amino-6-chloro-3;4-dihydroquinazoline; PD085853]
InChI Key
XXJMPUMRHCNWPW-UHFFFAOYSA-N
InChI
InChI=1S/C8H8ClN3/c9-6-1-2-7-5(3-6)4-11-8(10)12-7/h1-3H,4H2,(H3,10,11,12)
IUPAC Name
6-chloro-1,4-dihydroquinazolin-2-amine
CAS Number
183721-15-5

Structure Information

Chemical Structure Visualization

SMILES Notation
2D Molecular Drawing
Carbon (C)
Hydrogen (H)
Oxygen (O)
Nitrogen (N)
Sulfur (S)
SDF

20 21 0 0 0 0 0 0 0 0999 V2000
0.4897 -1.8115 -0.0862 C 0 0 0 0 0 0 0 0 0 0 0 0
-0.5391 -0.7080 -0.1151 C 0 0 0 0 0 0 0 0 0 0 0 0
-0.1573 0.617...

Experimental Data

Activity Data

Target Ion Channel
5-hydroxytryptamine receptor 3A
Uniprot Accession Number
Function
Antagonist
Species
Mus musculus (Mouse)
IC50
N/A (Not available)
EC50
N/A (Not available)
Ki
Ki: 80 nM
Kd
N/A (Not available)
Inhibition
N/A (Not available)

Experimental Conditions

pH
Not mention
Holding Potential
Not specified
Temperature
Not mention
Test Method
Binding assay ([3H] LY278584)
Test Species
Xenopus laevis oocyte

Binding Information

Binding Site
Not specified
Binding Site Residue
Not specified

Disease Information

Related Disease
Not specified

References

URL
N/A (Not available)
PMID
Patent
N/A (Not available)

Computed Properties

Heavy Atom Count
12
Rotatable Bonds
0
logP
1.5802
Complexity
50.4011
TPSA (Ų)
50.41
H-Bond Donors
2
H-Bond Acceptors
3
Ring Count
2
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